The show, which will be the band's penultimate live date of the year, will be available to viewers in 16 countries.
Commenting on the move, U2 manager Paul McGuinness said: "The band has wanted to do something like this for a long time. As we're filming the LA show, it's the perfect opportunity to extend the party beyond the stadium. Fans often travel long distances to come to see U2 - this time U2 can go to them, globally."
It's being reported that this is the first time a show of the size will be streamed on YouTube. Following the live broadcast, it'll be available on-demand as a standard YouTube video and also on U2's website.
A promo clip for the show is below. To watch the main event, go to youtube.com/U2 on Sunday 25 August at 8:30pm (Pacific Time).